[Hyperbaric oxygen and radiotherapy: From myth to reality].
Identifieur interne : 000027 ( France/Analysis ); précédent : 000026; suivant : 000028[Hyperbaric oxygen and radiotherapy: From myth to reality].
Auteurs : S. Espenel [France] ; C. Raffoux [France] ; A. Vallard [France] ; M-A Garcia [France] ; J-B Guy [France] ; C. Rancoule [France] ; M. Ben Mrad [France] ; J. Langrand-Escure [France] ; J-C Trone [France] ; G. Pigne [France] ; P. Diao [France] ; N. Magné [France]Source :
- Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique [ 1769-6658 ] ; 2016.
Descripteurs français
- KwdFr :
- Cystite (), Entérite (), Entérite (étiologie), Extraction dentaire, Humains, Lymphoedème (), Lymphoedème (étiologie), Maladies mandibulaires (), Neuropathies du plexus brachial (), Neuropathies du plexus brachial (étiologie), Ostéoradionécrose (), Oxygénation hyperbare, Radiodermite (), Radiothérapie (effets indésirables), Rectite (), Rectite (étiologie), Troubles de la cognition (), Troubles de la cognition (étiologie).
- MESH :
- effets indésirables : Radiothérapie.
- étiologie : Entérite, Lymphoedème, Neuropathies du plexus brachial, Rectite, Troubles de la cognition.
- Cystite, Entérite, Extraction dentaire, Humains, Lymphoedème, Maladies mandibulaires, Neuropathies du plexus brachial, Ostéoradionécrose, Oxygénation hyperbare, Radiodermite, Rectite, Troubles de la cognition.
English descriptors
- KwdEn :
- Brachial Plexus Neuropathies (etiology), Brachial Plexus Neuropathies (therapy), Cognition Disorders (etiology), Cognition Disorders (therapy), Cystitis (therapy), Enteritis (etiology), Enteritis (therapy), Humans, Hyperbaric Oxygenation, Lymphedema (etiology), Lymphedema (therapy), Mandibular Diseases (therapy), Osteoradionecrosis (therapy), Proctitis (etiology), Proctitis (therapy), Radiodermatitis (therapy), Radiotherapy (adverse effects), Tooth Extraction.
- MESH :
- adverse effects : Radiotherapy.
- etiology : Brachial Plexus Neuropathies, Cognition Disorders, Enteritis, Lymphedema, Proctitis.
- therapy : Brachial Plexus Neuropathies, Cognition Disorders, Cystitis, Enteritis, Lymphedema, Mandibular Diseases, Osteoradionecrosis, Proctitis, Radiodermatitis.
- Humans, Hyperbaric Oxygenation, Tooth Extraction.
Abstract
Worldwide, more than a million people receive each year a curative radiotherapy. While local control and overall survival are steadily increasing, 5 to 15% of patients still develop above grade 2 late toxicities. Late toxicities treatments are complex. Hyperbaric oxygenation was shown to induce revascularization and healing of injured tissues, but indications are still debated. Through a literature review, we summarized the hyperbaric oxygenation indications in radiation-induced late toxicities. We also studied the knowledge and practice of French local radiation therapists. It seems that hyperbaric oxygen therapy can be a conservative treatment of haemorrhagic cystitis and radiation-induced pain, in case of drug therapies failure. Often associated with a significant morbidity and mortality, surgery could be avoided. The risk of complications in case of tooth extraction in irradiated tissues is also reduced. However, the role of hyperbaric oxygenation for mandibular osteoradionecrosis, radiation-induced proctitis, enteritis, lymphoedema, brachial plexopathy, skin and neurological sequelae seems more questionable since studies results are conflicting. Future outcomes of phase III studies are expected to clarify the role of hyperbaric oxygenation in the management of radio-induced toxicities, including for head and necks complications.
DOI: 10.1016/j.canrad.2016.04.003
PubMed: 27342943
Affiliations:
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pubmed:27342943Le document en format XML
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Espenel</name><affiliation wicri:level="3"><nlm:affiliation>Département de radiothérapie, institut de cancérologie Lucien-Neuwirth, 108 bis, avenue Albert-Raimond, BP 60008, 42271 Saint-Priest-en-Jarez cedex, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Département de radiothérapie, institut de cancérologie Lucien-Neuwirth, 108 bis, avenue Albert-Raimond, BP 60008, 42271 Saint-Priest-en-Jarez cedex</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region><settlement type="city">Saint-Priest-en-Jarez</settlement></placeName></affiliation></author><author><name sortKey="Raffoux, C" sort="Raffoux, C" uniqKey="Raffoux C" first="C" last="Raffoux">C. 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Rancoule</name><affiliation wicri:level="3"><nlm:affiliation>Département de radiothérapie, institut de cancérologie Lucien-Neuwirth, 108 bis, avenue Albert-Raimond, BP 60008, 42271 Saint-Priest-en-Jarez cedex, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Département de radiothérapie, institut de cancérologie Lucien-Neuwirth, 108 bis, avenue Albert-Raimond, BP 60008, 42271 Saint-Priest-en-Jarez cedex</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region><settlement type="city">Saint-Priest-en-Jarez</settlement></placeName></affiliation></author><author><name sortKey="Ben Mrad, M" sort="Ben Mrad, M" uniqKey="Ben Mrad M" first="M" last="Ben Mrad">M. 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Pigne</name><affiliation wicri:level="3"><nlm:affiliation>Département de radiothérapie, institut de cancérologie Lucien-Neuwirth, 108 bis, avenue Albert-Raimond, BP 60008, 42271 Saint-Priest-en-Jarez cedex, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Département de radiothérapie, institut de cancérologie Lucien-Neuwirth, 108 bis, avenue Albert-Raimond, BP 60008, 42271 Saint-Priest-en-Jarez cedex</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region><settlement type="city">Saint-Priest-en-Jarez</settlement></placeName></affiliation></author><author><name sortKey="Diao, P" sort="Diao, P" uniqKey="Diao P" first="P" last="Diao">P. Diao</name><affiliation wicri:level="3"><nlm:affiliation>Département de radiothérapie, institut de cancérologie Lucien-Neuwirth, 108 bis, avenue Albert-Raimond, BP 60008, 42271 Saint-Priest-en-Jarez cedex, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Département de radiothérapie, institut de cancérologie Lucien-Neuwirth, 108 bis, avenue Albert-Raimond, BP 60008, 42271 Saint-Priest-en-Jarez cedex</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region><settlement type="city">Saint-Priest-en-Jarez</settlement></placeName></affiliation></author><author><name sortKey="Magne, N" sort="Magne, N" uniqKey="Magne N" first="N" last="Magné">N. Magné</name><affiliation wicri:level="3"><nlm:affiliation>Département de radiothérapie, institut de cancérologie Lucien-Neuwirth, 108 bis, avenue Albert-Raimond, BP 60008, 42271 Saint-Priest-en-Jarez cedex, France. Electronic address: nicolas.magne@icloire.fr.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Département de radiothérapie, institut de cancérologie Lucien-Neuwirth, 108 bis, avenue Albert-Raimond, BP 60008, 42271 Saint-Priest-en-Jarez cedex</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region><settlement type="city">Saint-Priest-en-Jarez</settlement></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:27342943</idno><idno type="pmid">27342943</idno><idno type="doi">10.1016/j.canrad.2016.04.003</idno><idno type="wicri:Area/PubMed/Corpus">000751</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000751</idno><idno type="wicri:Area/PubMed/Curation">000751</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000751</idno><idno type="wicri:Area/PubMed/Checkpoint">000751</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000751</idno><idno type="wicri:Area/Ncbi/Merge">008477</idno><idno type="wicri:Area/Ncbi/Curation">008477</idno><idno type="wicri:Area/Ncbi/Checkpoint">008477</idno><idno type="wicri:Area/Main/Merge">000898</idno><idno type="wicri:Area/Main/Curation">000897</idno><idno type="wicri:Area/Main/Exploration">000897</idno><idno type="wicri:Area/France/Extraction">000027</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">[Hyperbaric oxygen and radiotherapy: From myth to reality].</title><author><name sortKey="Espenel, S" sort="Espenel, S" uniqKey="Espenel S" first="S" last="Espenel">S. Espenel</name><affiliation wicri:level="3"><nlm:affiliation>Département de radiothérapie, institut de cancérologie Lucien-Neuwirth, 108 bis, avenue Albert-Raimond, BP 60008, 42271 Saint-Priest-en-Jarez cedex, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Département de radiothérapie, institut de cancérologie Lucien-Neuwirth, 108 bis, avenue Albert-Raimond, BP 60008, 42271 Saint-Priest-en-Jarez cedex</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region><settlement type="city">Saint-Priest-en-Jarez</settlement></placeName></affiliation></author><author><name sortKey="Raffoux, C" sort="Raffoux, C" uniqKey="Raffoux C" first="C" last="Raffoux">C. Raffoux</name><affiliation wicri:level="3"><nlm:affiliation>Département de médecine hyperbare, hôpital Édouard-Herriot, 5, place d'Arsonval, 69003 Lyon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Département de médecine hyperbare, hôpital Édouard-Herriot, 5, place d'Arsonval, 69003 Lyon</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Vallard, A" sort="Vallard, A" uniqKey="Vallard A" first="A" last="Vallard">A. Vallard</name><affiliation wicri:level="3"><nlm:affiliation>Département de radiothérapie, institut de cancérologie Lucien-Neuwirth, 108 bis, avenue Albert-Raimond, BP 60008, 42271 Saint-Priest-en-Jarez cedex, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Département de radiothérapie, institut de cancérologie Lucien-Neuwirth, 108 bis, avenue Albert-Raimond, BP 60008, 42271 Saint-Priest-en-Jarez cedex</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region><settlement type="city">Saint-Priest-en-Jarez</settlement></placeName></affiliation></author><author><name sortKey="Garcia, M A" sort="Garcia, M A" uniqKey="Garcia M" first="M-A" last="Garcia">M-A Garcia</name><affiliation wicri:level="3"><nlm:affiliation>Département de santé publique, centre Hygée, 108 bis, avenue Albert-Raimond, BP 60008, 42271 Saint-Priest-en-Jarez cedex, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Département de santé publique, centre Hygée, 108 bis, avenue Albert-Raimond, BP 60008, 42271 Saint-Priest-en-Jarez cedex</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region><settlement type="city">Saint-Priest-en-Jarez</settlement></placeName></affiliation></author><author><name sortKey="Guy, J B" sort="Guy, J B" uniqKey="Guy J" first="J-B" last="Guy">J-B Guy</name><affiliation wicri:level="3"><nlm:affiliation>Département de radiothérapie, institut de cancérologie Lucien-Neuwirth, 108 bis, avenue Albert-Raimond, BP 60008, 42271 Saint-Priest-en-Jarez cedex, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Département de radiothérapie, institut de cancérologie Lucien-Neuwirth, 108 bis, avenue Albert-Raimond, BP 60008, 42271 Saint-Priest-en-Jarez cedex</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region><settlement type="city">Saint-Priest-en-Jarez</settlement></placeName></affiliation></author><author><name sortKey="Rancoule, C" sort="Rancoule, C" uniqKey="Rancoule C" first="C" last="Rancoule">C. Rancoule</name><affiliation wicri:level="3"><nlm:affiliation>Département de radiothérapie, institut de cancérologie Lucien-Neuwirth, 108 bis, avenue Albert-Raimond, BP 60008, 42271 Saint-Priest-en-Jarez cedex, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Département de radiothérapie, institut de cancérologie Lucien-Neuwirth, 108 bis, avenue Albert-Raimond, BP 60008, 42271 Saint-Priest-en-Jarez cedex</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region><settlement type="city">Saint-Priest-en-Jarez</settlement></placeName></affiliation></author><author><name sortKey="Ben Mrad, M" sort="Ben Mrad, M" uniqKey="Ben Mrad M" first="M" last="Ben Mrad">M. Ben Mrad</name><affiliation wicri:level="3"><nlm:affiliation>Département de radiothérapie, institut de cancérologie Lucien-Neuwirth, 108 bis, avenue Albert-Raimond, BP 60008, 42271 Saint-Priest-en-Jarez cedex, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Département de radiothérapie, institut de cancérologie Lucien-Neuwirth, 108 bis, avenue Albert-Raimond, BP 60008, 42271 Saint-Priest-en-Jarez cedex</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region><settlement type="city">Saint-Priest-en-Jarez</settlement></placeName></affiliation></author><author><name sortKey="Langrand Escure, J" sort="Langrand Escure, J" uniqKey="Langrand Escure J" first="J" last="Langrand-Escure">J. Langrand-Escure</name><affiliation wicri:level="3"><nlm:affiliation>Département de radiothérapie, institut de cancérologie Lucien-Neuwirth, 108 bis, avenue Albert-Raimond, BP 60008, 42271 Saint-Priest-en-Jarez cedex, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Département de radiothérapie, institut de cancérologie Lucien-Neuwirth, 108 bis, avenue Albert-Raimond, BP 60008, 42271 Saint-Priest-en-Jarez cedex</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region><settlement type="city">Saint-Priest-en-Jarez</settlement></placeName></affiliation></author><author><name sortKey="Trone, J C" sort="Trone, J C" uniqKey="Trone J" first="J-C" last="Trone">J-C Trone</name><affiliation wicri:level="3"><nlm:affiliation>Département de radiothérapie, institut de cancérologie Lucien-Neuwirth, 108 bis, avenue Albert-Raimond, BP 60008, 42271 Saint-Priest-en-Jarez cedex, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Département de radiothérapie, institut de cancérologie Lucien-Neuwirth, 108 bis, avenue Albert-Raimond, BP 60008, 42271 Saint-Priest-en-Jarez cedex</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region><settlement type="city">Saint-Priest-en-Jarez</settlement></placeName></affiliation></author><author><name sortKey="Pigne, G" sort="Pigne, G" uniqKey="Pigne G" first="G" last="Pigne">G. Pigne</name><affiliation wicri:level="3"><nlm:affiliation>Département de radiothérapie, institut de cancérologie Lucien-Neuwirth, 108 bis, avenue Albert-Raimond, BP 60008, 42271 Saint-Priest-en-Jarez cedex, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Département de radiothérapie, institut de cancérologie Lucien-Neuwirth, 108 bis, avenue Albert-Raimond, BP 60008, 42271 Saint-Priest-en-Jarez cedex</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region><settlement type="city">Saint-Priest-en-Jarez</settlement></placeName></affiliation></author><author><name sortKey="Diao, P" sort="Diao, P" uniqKey="Diao P" first="P" last="Diao">P. Diao</name><affiliation wicri:level="3"><nlm:affiliation>Département de radiothérapie, institut de cancérologie Lucien-Neuwirth, 108 bis, avenue Albert-Raimond, BP 60008, 42271 Saint-Priest-en-Jarez cedex, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Département de radiothérapie, institut de cancérologie Lucien-Neuwirth, 108 bis, avenue Albert-Raimond, BP 60008, 42271 Saint-Priest-en-Jarez cedex</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region><settlement type="city">Saint-Priest-en-Jarez</settlement></placeName></affiliation></author><author><name sortKey="Magne, N" sort="Magne, N" uniqKey="Magne N" first="N" last="Magné">N. Magné</name><affiliation wicri:level="3"><nlm:affiliation>Département de radiothérapie, institut de cancérologie Lucien-Neuwirth, 108 bis, avenue Albert-Raimond, BP 60008, 42271 Saint-Priest-en-Jarez cedex, France. Electronic address: nicolas.magne@icloire.fr.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Département de radiothérapie, institut de cancérologie Lucien-Neuwirth, 108 bis, avenue Albert-Raimond, BP 60008, 42271 Saint-Priest-en-Jarez cedex</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region><settlement type="city">Saint-Priest-en-Jarez</settlement></placeName></affiliation></author></analytic><series><title level="j">Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique</title><idno type="eISSN">1769-6658</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Brachial Plexus Neuropathies (etiology)</term><term>Brachial Plexus Neuropathies (therapy)</term><term>Cognition Disorders (etiology)</term><term>Cognition Disorders (therapy)</term><term>Cystitis (therapy)</term><term>Enteritis (etiology)</term><term>Enteritis (therapy)</term><term>Humans</term><term>Hyperbaric Oxygenation</term><term>Lymphedema (etiology)</term><term>Lymphedema (therapy)</term><term>Mandibular Diseases (therapy)</term><term>Osteoradionecrosis (therapy)</term><term>Proctitis (etiology)</term><term>Proctitis (therapy)</term><term>Radiodermatitis (therapy)</term><term>Radiotherapy (adverse effects)</term><term>Tooth Extraction</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Cystite ()</term><term>Entérite ()</term><term>Entérite (étiologie)</term><term>Extraction dentaire</term><term>Humains</term><term>Lymphoedème ()</term><term>Lymphoedème (étiologie)</term><term>Maladies mandibulaires ()</term><term>Neuropathies du plexus brachial ()</term><term>Neuropathies du plexus brachial (étiologie)</term><term>Ostéoradionécrose ()</term><term>Oxygénation hyperbare</term><term>Radiodermite ()</term><term>Radiothérapie (effets indésirables)</term><term>Rectite ()</term><term>Rectite (étiologie)</term><term>Troubles de la cognition ()</term><term>Troubles de la cognition (étiologie)</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Radiotherapy</term></keywords><keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Radiothérapie</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Brachial Plexus Neuropathies</term><term>Cognition Disorders</term><term>Enteritis</term><term>Lymphedema</term><term>Proctitis</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Brachial Plexus Neuropathies</term><term>Cognition Disorders</term><term>Cystitis</term><term>Enteritis</term><term>Lymphedema</term><term>Mandibular Diseases</term><term>Osteoradionecrosis</term><term>Proctitis</term><term>Radiodermatitis</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Entérite</term><term>Lymphoedème</term><term>Neuropathies du plexus brachial</term><term>Rectite</term><term>Troubles de la cognition</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term><term>Hyperbaric Oxygenation</term><term>Tooth Extraction</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Cystite</term><term>Entérite</term><term>Extraction dentaire</term><term>Humains</term><term>Lymphoedème</term><term>Maladies mandibulaires</term><term>Neuropathies du plexus brachial</term><term>Ostéoradionécrose</term><term>Oxygénation hyperbare</term><term>Radiodermite</term><term>Rectite</term><term>Troubles de la cognition</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Worldwide, more than a million people receive each year a curative radiotherapy. While local control and overall survival are steadily increasing, 5 to 15% of patients still develop above grade 2 late toxicities. Late toxicities treatments are complex. Hyperbaric oxygenation was shown to induce revascularization and healing of injured tissues, but indications are still debated. Through a literature review, we summarized the hyperbaric oxygenation indications in radiation-induced late toxicities. We also studied the knowledge and practice of French local radiation therapists. It seems that hyperbaric oxygen therapy can be a conservative treatment of haemorrhagic cystitis and radiation-induced pain, in case of drug therapies failure. Often associated with a significant morbidity and mortality, surgery could be avoided. The risk of complications in case of tooth extraction in irradiated tissues is also reduced. However, the role of hyperbaric oxygenation for mandibular osteoradionecrosis, radiation-induced proctitis, enteritis, lymphoedema, brachial plexopathy, skin and neurological sequelae seems more questionable since studies results are conflicting. Future outcomes of phase III studies are expected to clarify the role of hyperbaric oxygenation in the management of radio-induced toxicities, including for head and necks complications.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Auvergne-Rhône-Alpes</li><li>Rhône-Alpes</li></region><settlement><li>Lyon</li><li>Saint-Priest-en-Jarez</li></settlement></list><tree><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Espenel, S" sort="Espenel, S" uniqKey="Espenel S" first="S" last="Espenel">S. Espenel</name></region><name sortKey="Ben Mrad, M" sort="Ben Mrad, M" uniqKey="Ben Mrad M" first="M" last="Ben Mrad">M. Ben Mrad</name><name sortKey="Diao, P" sort="Diao, P" uniqKey="Diao P" first="P" last="Diao">P. Diao</name><name sortKey="Garcia, M A" sort="Garcia, M A" uniqKey="Garcia M" first="M-A" last="Garcia">M-A Garcia</name><name sortKey="Guy, J B" sort="Guy, J B" uniqKey="Guy J" first="J-B" last="Guy">J-B Guy</name><name sortKey="Langrand Escure, J" sort="Langrand Escure, J" uniqKey="Langrand Escure J" first="J" last="Langrand-Escure">J. Langrand-Escure</name><name sortKey="Magne, N" sort="Magne, N" uniqKey="Magne N" first="N" last="Magné">N. Magné</name><name sortKey="Pigne, G" sort="Pigne, G" uniqKey="Pigne G" first="G" last="Pigne">G. Pigne</name><name sortKey="Raffoux, C" sort="Raffoux, C" uniqKey="Raffoux C" first="C" last="Raffoux">C. Raffoux</name><name sortKey="Rancoule, C" sort="Rancoule, C" uniqKey="Rancoule C" first="C" last="Rancoule">C. Rancoule</name><name sortKey="Trone, J C" sort="Trone, J C" uniqKey="Trone J" first="J-C" last="Trone">J-C Trone</name><name sortKey="Vallard, A" sort="Vallard, A" uniqKey="Vallard A" first="A" last="Vallard">A. Vallard</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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